Fiona powrie biography
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Fiona Powrie, PhD
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Fiona Powrie
Sidney Truelove Professor of Gastroenterology
Dame Fiona Margaret PowrieDBE FRS FMedSci (born ) is currently the head of the Kennedy Institute of Rheumatology at the University of Oxford.[2] Formerly she was the inaugural Sidney Truelove Professor of Gastroenterology at the University of Oxford. She is also head of the Experimental Medicine Division of the Nuffield Department of Clinical Medicine.[3]
Career
[edit]Powrie studied biochemistry at the University of Bath,[4] before completing a DPhil degree in Don Mason's lab at the Sir William Dunn School of Pathology, the University of Oxford.[5]
Notable work
[edit]Regulatory T cells
[edit]Powrie worked with Don Mason at the Sir William Dunn School of Pathology studying the interactions of different subsets of CD4+ T cells in rats. This work identified that CD4+OX22hi (OX22 is CD45RC in rats and the equivalent of CD45RB in mice, both isoforms of CD45[6&# • Dame Fiona Powrie is Director of the Kennedy Institute of Rheumatology and a Professor of Musculoskeletal Sciences at the University of Oxford. Her research interests include characterising the interaction between the intestinal microbiota and the host immune system and how this mutualistic relationship breaks down in inflammatory bowel disease. Her work has identified the functional role of regulatory T cells in intestinal homeostasis and shed light on their development and mechanism of action. She has also shown that both adaptive and innate immune mechanisms contribute to intestinal inflammation and identified the IL pathway as a pivotal player in the pathogenesis of chronic intestinal inflammation. Her current work seeks to translate findings from model systems into the clinic in inflammatory bowel disease patients. Fiona received the Ita Askonas Award from the European Federation of Immunological Societies for her contribution to immunology in Europe, followed by the Louis-